rs174570
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 |
| Make rs174570(C;T) |
| Make rs174570(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 61829740 |
| Gene | FADS2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs174570 |
| dbSNP (classic) | rs174570 |
| ClinGen | rs174570 |
| ebi | rs174570 |
| HLI | rs174570 |
| Exac | rs174570 |
| Gnomad | rs174570 |
| Varsome | rs174570 |
| LitVar | rs174570 |
| Map | rs174570 |
| PheGenI | rs174570 |
| Biobank | rs174570 |
| 1000 genomes | rs174570 |
| hgdp | rs174570 |
| ensembl | rs174570 |
| geneview | rs174570 |
| scholar | rs174570 |
| rs174570 | |
| pharmgkb | rs174570 |
| gwascentral | rs174570 |
| openSNP | rs174570 |
| 23andMe | rs174570 |
| SNPshot | rs174570 |
| SNPdbe | rs174570 |
| MSV3d | rs174570 |
| GWAS Ctlg | rs174570 |
| GMAF | 0.2351 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
per the 23andMe blog, the minor allele of this SNP (T) was associated with decreased cholesterol and increased triglycerides
| SNP | Rarer allele | LDL | HDL | TG |
|---|---|---|---|---|
| rs6544713 | T | + | ||
| rs2650000 | A | + | ||
| rs471364 | C | - | ||
| rs1800961 | T | - | ||
| rs7679 | C | - | + | |
| rs2967605 | T | - | ||
| rs2409722 | T | - | ||
| rs10903129 | A | - | - | - |
| rs6756629 | A | - | + | - |
| rs12670798 | C | + | + | + |
| rs7395662 | A | - | + | + |
| rs174570 | T | - | - | + |
| rs2271293 | A | - | + | - |
| rs2624265 | C | + | ||
| rs2167079 | T | + | ||
| rs9891572 | T | + | ||
| rs4844614 | T | + | ||
| rs5031002 | G | + |
| GWAS snp | |
|---|---|
| PMID | [PMID 19060911 ]
|
| Trait | Cholesterol, total |
| Title | Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts |
| Risk Allele | G |
| P-val | 2E-10 |
| Odds Ratio | 0.09 [NR] SD increase |
[PMID 20484448] Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study
[PMID 19798445] Genetic determinants of circulating sphingolipid concentrations in European populations.
[PMID 19944404] Genomic dissection of population substructure of Han Chinese and its implication in association studies.
[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
[PMID 20502693] Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
[PMID 20565855] Genetic variation in lipid desaturases and its impact on the development of human disease.
[PMID 21383846] Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.
rs7115739 and rs174570 http://www.sciencemag.org/content/349/6254/1343.full Greenlandic Inuit show genetic signatures of diet and climate adaptation
| GWAS snp | |
|---|---|
| PMID | [PMID 24647736]
|
| Trait | Glycated hemoglobin levels |
| Title | Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. |
| Risk Allele | C |
| P-val | 2E-7 |
| Odds Ratio | .04 [0.020-0.060] unit increase |
